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Primary care doctor's office
Brightleaf Square

Our beautiful and calming Brightleaf Square office, just down the road from our specialist partners at Duke Health, is designed to make it faster, easier, and more enjoyable to get exceptional care when you need it. We’ve redesigned every aspect of our primary care practice around your needs and your life — from same-day appointments that actually start on time to 24/7 video visits with our app to compassionate providers who listen. And we’re not just here for when you’re sick or injured. We can also help you meet physical and mental health goals, manage chronic illnesses, and live a happier, healthier life. And our members have easy access to more than 2,000 world-class specialists in the Duke Health system. Think of us as your healthcare home base.

Office Hours

Office Hours:
Mon–Fri: 8AM–5PM
Sat–Sun: Closed
Lab Hours:
Closed every day


10:00AM 60 min
11:00AM 25 min
11:45AM 60 min
10:00AM 60 min
Book online today
Schedule an appointment, online or in-app, today. Become a One Medical member for just $199/year.


905 W Main Street

Suite 18A

Durham, NC 27701



Get Directions

Location details

Our office is located off of W Main and S Gregson Street. Please note this area is under construction, which can create parking confusion and traffic delays.


There is 2 hr free parking lot that is accessible from S Duke Street that is specifically for Brightleaf Square customers. Additional parking is available on W Main Street. If entering the building from the W Main street entrance, you must walk through the building to the courtyard and walk to the left to find our office.