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Primary Care Doctor's Office in Durham, NC Brightleaf Square

Our Brightleaf Square office offers exceptional primary care for adults of all ages, including seniors on Medicare. We’ve designed our member experience for real life — from same-day appointments that start on time to 24/7 video chat to compassionate providers who listen. We focus on building real relationships with patients and using technology to simplify every aspect of getting care. And we’re not just here for when you’re sick or injured. We can also help you meet physical and mental health goals, manage chronic illnesses, and live a happier, healthier life. Plus, you can expect improved coordination of specialty care through our affiliation with Duke Health. Think of us as your home for healthcare.

Join One Medical

Interested in becoming a member or learning more about One Medical?

Membership benefits you’ll enjoy

  • Get 24/7 on-demand care nationwide via Video Chat or Treat Me Now at no extra cost
  • Send and receive secure messages with a provider
  • Easily access your health records and care plans
  • Request prescription refills and renewals
  • Book an in-person or remote visit in a state where we have offices

905 W Main Street

Suite 18A

Durham , NC 27701

Get Directions

Contact us:

Office Hours:

Mon–Fri: 8AM–5PM
Sat–Sun: Closed

Special Hours (Office and Lab):
07/04 Thu Closed

Lab Hours:

Mon–Fri: 8AM–12PM, 1PM–4PM
Sat–Sun: Closed
LAB CLOSURE: The lab will be closed on Friday, June 28th.


Location details

Our office is located off of W Main and S Gregson Street.


There is 2 hr free parking lot that is accessible from S Duke Street that is specifically for Brightleaf Square customers. Additional parking is available on W Main Street. If entering the building from the W Main street entrance, you must walk through the building to the courtyard and walk to the left to find our office.

Our services

Think of us as your home for healthcare — your go-to for preventive care like physicals and screenings and your first stop when something feels off.

Frequently asked questions