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Primary Care Doctor's Office in Durham, NC Brightleaf Square

Our beautiful and calming Brightleaf Square office, just down the road from our specialist partners at Duke Health, is designed to make it faster, easier, and more enjoyable to get exceptional care when you need it. We’ve redesigned every aspect of our primary care practice around your needs and your life — from same-day appointments that actually start on time to 24/7 video visits with our app to compassionate providers who listen. And we’re not just here for when you’re sick or injured. We can also help you meet physical and mental health goals, manage chronic illnesses, and live a happier, healthier life. And our members have easy access to more than 2,000 world-class specialists in the Duke Health system. Think of us as your home for healthcare.

Join One Medical

Interested in becoming a patient or learning more about One Medical?

Membership benefits you’ll enjoy

  • Get 24/7 on-demand care nationwide via Video Chat or Treat Me Now at no extra cost
  • Send and receive secure messages with a provider
  • Easily access your health records and care plans
  • Request prescription refills and renewals
  • Book an in-person or remote visit in a state where we have offices

905 W Main Street

Suite 18A

Durham , NC 27701

Get Directions

Contact us:

Office Hours:

Mon–Fri: 8AM–5PM
Sat–Sun: Closed

Lab Hours:

Mon–Fri: 8AM–12PM, 1PM–4PM
Sat–Sun: Closed
UPCOMING LAB CLOSURE: The lab will be closed after noon on Friday, February 23rd.


Location details

Our office is located off of W Main and S Gregson Street.


There is 2 hr free parking lot that is accessible from S Duke Street that is specifically for Brightleaf Square customers. Additional parking is available on W Main Street. If entering the building from the W Main street entrance, you must walk through the building to the courtyard and walk to the left to find our office.

Our services

Think of us as your home for healthcare — your go-to for preventive care like physicals and screenings and your first stop when something feels off.

Frequently asked questions