Sf Bay Transbay Center Office
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Transbay Center

Our Transbay Center doctor's office is conveniently located on Mission Street in SoMa. One Medical provides a fresh new approach to primary care and can help with anything from allergies to STD testing, colds to lipid disorders, and stress management. Throw away everything you've come to expect from health care - we're changing the way you think about your doctor with same-day appointments and a modern approach.

Office Hours

Office Hours:
Mon–Fri: 8AM–5PM
Sat–Sun: Closed
Lab Hours:
Mon, Tue, Thu: 8AM–12PM, 1PM–3:30PM
Wed, Fri: 8AM–12PM, 1:15PM–3:30PM
Sat–Sun: Closed


10:00AM 60 min
11:00AM 25 min
11:45AM 60 min
10:00AM 60 min
See a provider
Book an appointment online today. Become a One Medical member for just $199/year.


535 Mission Street

Suite 100

San Francisco, CA 94105




Public Transportation

  • F train to Market and 1st or 2nd Street
  • K-Owl, L-Owl, N-Owl, 2, 5, 5R, 6, 7, 7R, 9, 9R, and 21 all run nearby
San Francisco Metro Transit Home
  • All lines to Montgomery


There are parking garages located nearby at 101 2nd Street (ABM Parking Services), 535 Mission (Impark), 100 1st Street (Standard Parking), and 555 Mission (Standard Parking). These parking garages are not affiliated with One Medical. There is limited, metered street parking available.

Additional Information

Our Transbay Center doctor's office is located between 1st Street and 2nd Street, next to Salt House restaurant. There is bike parking in front of the building.

Be aware that we also have an office in the Mission district on Valencia Street. Our Transbay Center office is in SoMa.